Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 7/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 7/20 | 0.35 |
| ▸ | MTHFD2 | P13995 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | CLPP | Q16740 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23973585 | 1.00 | ROCK2 (0.41) | ROCK2CYP3A4HPGDTNKSTNKS2 | |
| SCHEMBL28933154 | 1.00 | ROCK2 (0.41) | ROCK2CYP3A4HPGDTNKSTNKS2 | |
| SCHEMBL23973764 | 0.96 | ROCK2 (0.41) | ROCK2CYP3A4HPGDTNKSTNKS2 | |
| SCHEMBL23972565 | 0.95 | ROCK2 (0.37) | ROCK2CYP3A4HPGDTNKSTNKS2 | |
| SCHEMBL31406781 | 0.95 | ROCK2 (0.37) | ROCK2CYP3A4HPGDTNKSTNKS2 | |
| SCHEMBL28933100 | 0.95 | ROCK2 (0.37) | ROCK2CYP3A4HPGDTNKSTNKS2 | |
| SCHEMBL23972876 | 0.95 | ROCK2 (0.39) | ROCK2CYP3A4HPGDTNKSTNKS2 | |
| SCHEMBL23973646 | 0.95 | ROCK2 (0.37) | ROCK2CYP3A4HPGDTNKSTNKS2 | |
| SCHEMBL30284256 | 0.95 | ROCK2 (0.39) | ROCK2CYP3A4HPGDTNKSTNKS2 | |
| SCHEMBL30284146 | 0.95 | ROCK2 (0.37) | ROCK2CYP3A4HPGDTNKSTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4142874-B1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | RAQUALIA PHARMA INC (JP) | 2026-04-22 | — | — | EP | claimed |
| CN-115427409-B | Pyrimidine-4 (3H) -one derivatives as TRPV4 antagonists | 拉夸里亚创药株式会社 | 2025-02-25 | — | — | CN | claimed |
| CN-115427409-B | Pyrimidine-4 (3H) -one derivatives as TRPV4 antagonists | 拉夸里亚创药株式会社 | 2025-02-25 | — | — | CN | disclosed |
| CN-115776890-A | TRPV4 inhibitors as therapeutic agents for eye diseases | 拉夸里亚创药株式会社 | 2023-03-10 | — | — | CN | disclosed |