Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTHFD2 | P13995 | 8/20 | 0.42 |
| ▸ | CLPP | Q16740 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | SPR | P35270 | 3/20 | 0.32 |
| ▸ | PRLHR | P49683 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23973755 | 1.00 | MTHFD2 (0.42) | MTHFD2CLPPROCK2CYP3A4SPR | |
| SCHEMBL23973058 | 0.91 | MTHFD2 (0.46) | MTHFD2CLPPROCK2CYP3A4SPR | |
| SCHEMBL26672673 | 0.91 | MTHFD2 (0.46) | MTHFD2CLPPROCK2CYP3A4SPR | |
| SCHEMBL23972403 | 0.90 | MTHFD2 (0.41) | MTHFD2CLPPROCK2CYP3A4SPR | |
| SCHEMBL26672689 | 0.90 | MTHFD2 (0.41) | MTHFD2CLPPMAPT | |
| SCHEMBL23972667 | 0.90 | MTHFD2 (0.44) | MTHFD2CLPPMAPT | |
| SCHEMBL30284285 | 0.90 | MTHFD2 (0.41) | MTHFD2CLPPROCK2CYP3A4SPR | |
| SCHEMBL23972795 | 0.89 | MTHFD2 (0.41) | MTHFD2CLPPROCK2CYP3A4SPR | |
| SCHEMBL23972844 | 0.89 | MTHFD2 (0.41) | MTHFD2CLPPROCK2CYP3A4SPR | |
| SCHEMBL23973772 | 0.89 | MTHFD2 (0.41) | MTHFD2CLPPROCK2CYP3A4SPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4142874-B1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | RAQUALIA PHARMA INC (JP) | 2026-04-22 | — | — | EP | claimed |
| CN-115427409-B | Pyrimidine-4 (3H) -one derivatives as TRPV4 antagonists | 拉夸里亚创药株式会社 | 2025-02-25 | — | — | CN | claimed |
| CN-115427409-B | Pyrimidine-4 (3H) -one derivatives as TRPV4 antagonists | 拉夸里亚创药株式会社 | 2025-02-25 | — | — | CN | disclosed |
| CN-115776890-A | TRPV4 inhibitors as therapeutic agents for eye diseases | 拉夸里亚创药株式会社 | 2023-03-10 | — | — | CN | disclosed |