Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTHFD2 | P13995 | 8/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | CLPP | Q16740 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23973002 | 1.00 | MTHFD2 (0.37) | MTHFD2TRPV1CLPPMAPTKDR | |
| SCHEMBL23973004 | 0.96 | MEN1 (0.34) | MTHFD2TRPV1CLPPMAPTKDR | |
| SCHEMBL30284029 | 0.96 | MEN1 (0.34) | MTHFD2TRPV1CLPPMAPTKDR | |
| SCHEMBL23972793 | 0.95 | TRPV1 (0.38) | MTHFD2TRPV1CLPPMAPTKDR | |
| SCHEMBL30284337 | 0.95 | TRPV1 (0.38) | MTHFD2TRPV1CLPPMAPTKDR | |
| SCHEMBL23973435 | 0.93 | MEN1 (0.39) | MTHFD2TRPV1CLPPKDR | |
| SCHEMBL30283803 | 0.93 | MEN1 (0.39) | MTHFD2TRPV1CLPPKDR | |
| SCHEMBL30283851 | 0.93 | MTHFD2 (0.41) | MTHFD2TRPV1CLPPMAPTKDR | |
| SCHEMBL23972801 | 0.93 | MTHFD2 (0.41) | MTHFD2TRPV1CLPPMAPTKDR | |
| SCHEMBL34464288 | 0.91 | MEN1 (0.36) | MTHFD2CLPPMAPTKDROPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4142874-B1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | RAQUALIA PHARMA INC (JP) | 2026-04-22 | — | — | EP | claimed |
| CN-115427409-B | Pyrimidine-4 (3H) -one derivatives as TRPV4 antagonists | 拉夸里亚创药株式会社 | 2025-02-25 | — | — | CN | claimed |
| CN-115427409-B | Pyrimidine-4 (3H) -one derivatives as TRPV4 antagonists | 拉夸里亚创药株式会社 | 2025-02-25 | — | — | CN | disclosed |
| CN-115776890-A | TRPV4 inhibitors as therapeutic agents for eye diseases | 拉夸里亚创药株式会社 | 2023-03-10 | — | — | CN | disclosed |