Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 11/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.47 |
| ▸ | PIM1 | P11309 | 3/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30285592 | 0.88 | PRMT5 (0.44) | MAPK1PRMT5WDR77PIM1PIM2 | |
| SCHEMBL25321038 | 0.71 | PARP1 (0.36) | PIM1CDC7 | |
| SCHEMBL25322726 | 0.70 | PARP1 (0.35) | PIM1CDC7 | |
| SCHEMBL5863676 | 0.68 | CDC7 (0.40) | MAPK1CDC7 | |
| SCHEMBL31553851 | 0.68 | CDC7 (0.40) | MAPK1CDC7 | |
| SCHEMBL25925662 | 0.68 | PARP10 (0.37) | MAPK1CDC7DBF4 | |
| SCHEMBL5863725 | 0.68 | PARP10 (0.51) | MAPK1PIM1CDC7JAK2 | |
| SCHEMBL12457586 | 0.68 | PARP10 (0.51) | CDC7 | |
| SCHEMBL30285326 | 0.68 | PARP10 (0.51) | MAPK1PIM1CDC7JAK2 | |
| SCHEMBL30285524 | 0.68 | PRMT5 (0.47) | MAPK1PRMT5WDR77PIM1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111825656-B | Inhibitors of protein arginine methyltransferase 5 (PRMT 5), pharmaceutical products thereof, and methods thereof | 南京药石科技股份有限公司 | 2023-03-31 | — | — | CN | disclosed |