Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 4/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25321038 | 0.99 | PARP1 (0.36) | PARP1GSK3BCDC7GPR35NTRK1 | |
| SCHEMBL25322845 | 0.85 | GPR35 (0.37) | GSK3BGPR35MKNK1 | |
| SCHEMBL30551433 | 0.85 | GPR35 (0.37) | GSK3BGPR35MKNK1 | |
| SCHEMBL25322394 | 0.79 | ALDH1A1 (0.41) | PIM1CYP1A2GRM5 | |
| SCHEMBL25908287 | 0.77 | GRM5 (0.39) | GRM5 | |
| SCHEMBL25324444 | 0.75 | CYP1A2 (0.38) | CYP1A2GRM5 | |
| SCHEMBL30285592 | 0.71 | PRMT5 (0.44) | PARP1CDC7BRD4MKNK1PARP10 | |
| SCHEMBL30285390 | 0.70 | MAPK1 (0.50) | CDC7PIM1 | |
| SCHEMBL12457586 | 0.69 | PARP10 (0.51) | PARP1CDC7PARP10GRM5 | |
| SCHEMBL5863725 | 0.69 | PARP10 (0.51) | PARP1GSK3BCDC7NTRK1MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4469455-A1 | COMPOUNDS AND METHODS OF USE | Tango Therapeutics, Inc. (US) | 2024-12-04 | — | — | EP | disclosed |
| WO-2023146990-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |