Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 19/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11963218 | 0.85 | TRPV4 (0.48) | TRPV4CYP11B1CYP11B2 | |
| SCHEMBL19128162 | 0.81 | TRPV4 (0.48) | TRPV4CYP11B1CYP11B2 | |
| SCHEMBL772850 | 0.80 | TRPV4 (0.51) | TRPV4 | |
| SCHEMBL7323185 | 0.79 | CYP11B1 (0.65) | TRPV4CYP11B1CYP11B2 | |
| SCHEMBL559898 | 0.77 | TRPV4 (0.48) | TRPV4CYP11B1CYP11B2 | |
| SCHEMBL14299588 | 0.77 | TRPV4 (0.47) | TRPV4 | |
| SCHEMBL23674346 | 0.77 | TRPV4 (0.46) | TRPV4CYP11B1CYP11B2 | |
| SCHEMBL3565152 | 0.77 | CYP11B1 (0.45) | TRPV4CYP11B1CYP11B2 | |
| SCHEMBL13481174 | 0.77 | CYP11B1 (0.51) | TRPV4CYP11B1CYP11B2 | |
| SCHEMBL9244079 | 0.77 | CYP11B1 (0.51) | TRPV4CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4396176-A1 | INDOLE COMPOUNDS AND USES THEREOF IN THE TREATEMENT OF CYSTIC FIBROSIS | GENZYME CORPORATION (US) | 2024-07-10 | — | — | EP | disclosed |
| WO-2023034946-A1 | INDOLE COMPOUNDS AND USES THEREOF IN THE TREATEMENT OF CYSTIC FIBROSIS | GENZYME CORPORATION (US) | 2023-03-09 | — | — | WO | disclosed |