Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.50 |
| ▸ | PNMT | P11086 | 2/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | TDP2 | O95551 | 2/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21333673 | 1.00 | TSHR (0.60) | TSHRPARP10ADRA2APNMTADRA2B | |
| SCHEMBL2170999 | 0.87 | TSHR (0.60) | TSHRPARP10ADRA2APNMTADRA2B | |
| SCHEMBL3308170 | 0.87 | TSHR (0.60) | TSHRPARP10ADRA2APNMTADRA2B | |
| SCHEMBL21470711 | 0.83 | TSHR (0.60) | TSHRTDP2PBRM1CDC7MKNK1 | |
| SCHEMBL30697867 | 0.77 | PNMT (0.62) | ADRA2APNMTADRA2BADRA2CCMA1 | |
| SCHEMBL793093 | 0.76 | TSHR (0.55) | TSHRPARP10PNMTPARP1TDP2 | |
| SCHEMBL6448571 | 0.75 | TSHR (1.00) | TSHRPARP10PARP1TDP2MKNK1 | |
| SCHEMBL12203700 | 0.75 | TSHR (1.00) | TSHRPARP10PARP1TDP2MKNK1 | |
| SCHEMBL8247179 | 0.75 | PNMT (0.57) | TSHRADRA2APNMTADRA2BADRA2C | |
| SCHEMBL20288981 | 0.75 | PBRM1 (0.51) | TSHRPARP10ADRA2APNMTADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111825656-B | Inhibitors of protein arginine methyltransferase 5 (PRMT 5), pharmaceutical products thereof, and methods thereof | 南京药石科技股份有限公司 | 2023-03-31 | — | — | CN | disclosed |