Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.37 |
| ▸ | RHEB | Q15382 | 5/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29237632 | 1.00 | TRPA1 (0.37) | TRPA1RHEBDRD1HTR2BTRPM8 | |
| SCHEMBL29336972 | 0.84 | TRPA1 (0.34) | TRPA1RHEBDRD1HTR2BHTR2A | |
| SCHEMBL30285487 | 0.84 | TRPA1 (0.34) | TRPA1RHEBDRD1HTR2BHTR2A | |
| SCHEMBL31176898 | 0.83 | TRPA1 (0.39) | TRPA1RHEBDRD1GPR84 | |
| SCHEMBL31065974 | 0.81 | RHEB (0.38) | TRPA1RHEBDRD1GPR84 | |
| SCHEMBL31066001 | 0.80 | RHEB (0.43) | TRPA1RHEBDRD1GPR84MEN1 | |
| SCHEMBL27382327 | 0.78 | TRPA1 (0.36) | TRPA1RHEBDRD1 | |
| SCHEMBL31065957 | 0.77 | DRD1 (0.35) | TRPA1RHEBDRD1GPR84 | |
| SCHEMBL29237289 | 0.77 | TRPA1 (0.37) | TRPA1RHEBDRD1GPR84 | |
| SCHEMBL27382323 | 0.77 | DRD1 (0.40) | TRPA1RHEBDRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4396176-A1 | INDOLE COMPOUNDS AND USES THEREOF IN THE TREATEMENT OF CYSTIC FIBROSIS | GENZYME CORPORATION (US) | 2024-07-10 | — | — | EP | disclosed |
| CN-118201919-A | Indole compounds and methods of use | 健赞公司 | 2024-06-14 | — | — | CN | disclosed |
| WO-2023034946-A1 | INDOLE COMPOUNDS AND USES THEREOF IN THE TREATEMENT OF CYSTIC FIBROSIS | GENZYME CORPORATION (US) | 2023-03-09 | — | — | WO | disclosed |