Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 8/20 | 0.48 |
| ▸ | PARP1 | P09874 | 6/20 | 0.48 |
| ▸ | F7 | P08709 | 1/20 | 0.48 |
| ▸ | F3 | P13726 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | WEE1 | P30291 | 2/20 | 0.41 |
| ▸ | PARP11 | Q9NR21 | 3/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.37 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30285550 | 0.79 | MKNK1 (0.55) | PRMT5WDR77MKNK1PARP10PARP1 | |
| SCHEMBL30285395 | 0.78 | PARP10 (0.50) | PRMT5WDR77MKNK1PARP10PARP1 | |
| SCHEMBL10157871 | 0.72 | MKNK1 (0.45) | MKNK1PARP10PARP1F7F3 | |
| SCHEMBL30285547 | 0.72 | PARP10 (0.52) | PRMT5WDR77MKNK1PARP10PARP1 | |
| SCHEMBL2027837 | 0.71 | PARP10 (0.63) | MKNK1PARP10PARP1F7F3 | |
| SCHEMBL30285534 | 0.71 | PARP10 (0.51) | PRMT5WDR77MKNK1PARP10PARP1 | |
| SCHEMBL13663549 | 0.70 | MKNK1 (0.45) | MKNK1PARP10PARP1F7F3 | |
| SCHEMBL30683574 | 0.70 | PARP10 (0.56) | MKNK1PARP10PARP1F7F3 | |
| SCHEMBL21460002 | 0.68 | PARP10 (0.58) | MKNK1PARP10PARP1F7F3 | |
| SCHEMBL11906514 | 0.67 | PARP10 (0.56) | MKNK1PARP10PARP1F7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111825656-B | Inhibitors of protein arginine methyltransferase 5 (PRMT 5), pharmaceutical products thereof, and methods thereof | 南京药石科技股份有限公司 | 2023-03-31 | — | — | CN | claimed |
| CN-111825656-B | Inhibitors of protein arginine methyltransferase 5 (PRMT 5), pharmaceutical products thereof, and methods thereof | 南京药石科技股份有限公司 | 2023-03-31 | — | — | CN | disclosed |