Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 7/20 | 0.44 |
| ▸ | PARP1 | P09874 | 6/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.44 |
| ▸ | WEE1 | P30291 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 5/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
| ▸ | PARP11 | Q9NR21 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8160226 | 0.80 | POLB (0.48) | POLB | |
| SCHEMBL10127120 | 0.77 | PARP1 (0.39) | MKNK1PARP10PARP1F7F3 | |
| SCHEMBL17340295 | 0.76 | PARP1 (0.38) | MKNK1PARP10PARP1F7F3 | |
| SCHEMBL30285609 | 0.72 | PRMT5 (0.49) | MKNK1PARP10PARP1F7F3 | |
| SCHEMBL10156777 | 0.72 | POLB (0.42) | POLB | |
| SCHEMBL10156550 | 0.70 | POLB (0.48) | POLB | |
| SCHEMBL10156704 | 0.69 | ROCK1 (0.45) | MAPK1POLBCCNA2CDK2 | |
| SCHEMBL13663549 | 0.69 | MKNK1 (0.45) | MKNK1PARP10PARP1F7F3 | |
| SCHEMBL30285547 | 0.69 | PARP10 (0.52) | MKNK1PARP10PARP1F7F3 | |
| SCHEMBL30285550 | 0.68 | MKNK1 (0.55) | MKNK1PARP10PARP1F7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040968-A1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | WATERS TECHNOLOGIES CORPORATION (US) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040968-A1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | EML4, ALK, ERBB4 | MKNK1 572/4885PARP10 667/4885PARP1 1748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.