Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NOS1 | P29475 | 2/20 | 0.44 |
| ▸ | METAP2 | P50579 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18554980 | 1.00 | AXL (0.56) | AXLMAPTTSHRNPC1RAB9A | |
| SCHEMBL31602581 | 0.94 | AXL (0.53) | AXLMAPTTSHRNPC1RAB9A | |
| SCHEMBL18183739 | 0.83 | TSHR (0.49) | AXLMAPTTSHRNPC1RAB9A | |
| SCHEMBL617024 | 0.83 | AXL (0.53) | AXLMAPTNPC1RAB9ANOS1 | |
| SCHEMBL31041189 | 0.82 | TSHR (0.55) | AXLMAPTTSHRNPC1RAB9A | |
| SCHEMBL1273838 | 0.82 | TSHR (0.55) | AXLMAPTTSHRNPC1RAB9A | |
| SCHEMBL15687581 | 0.82 | TSHR (0.47) | AXLMAPTTSHRNPC1RAB9A | |
| SCHEMBL30584955 | 0.82 | TSHR (0.47) | AXLMAPTTSHRNPC1RAB9A | |
| SCHEMBL22446005 | 0.81 | TSHR (0.50) | AXLMAPTTSHRNPC1RAB9A | |
| SCHEMBL22446038 | 0.81 | CASP6 (0.54) | AXLMAPTNPC1RAB9ANOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115873007-A | Condensed tetracyclic derivative, preparation method and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2023-03-31 | — | — | CN | disclosed |