Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.45 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.45 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.45 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.45 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.45 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CASP2 | P42575 | 1/20 | 0.48 |
| ▸ | RAD52 | P43351 | 3/20 | 0.47 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.47 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3841369 | 1.00 | KMT2A (0.48) | KMT2ASMN1; SMN2MEN1MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL28410655 | 1.00 | KMT2A (0.48) | KMT2ASMN1; SMN2MEN1MAPTMAPK1 | |
| SCHEMBL27656267 | 0.98 | CHRM2 (0.47) | KMT2ASMN1; SMN2MEN1MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL28065870 | 0.98 | KMT2A (0.45) | KMT2ASMN1; SMN2MEN1MAPTMAPK1 | |
| SCHEMBL2563316 | 0.98 | CHRM2 (0.47) | KMT2ASMN1; SMN2MEN1MAPTMAPK1 | |
| SCHEMBL1168955 | 0.98 | CHRM2 (0.47) | KMT2ASMN1; SMN2MEN1MAPTMAPK1 | |
| Bromide SCHEMBL28419938 | 0.96 | RAD52 (0.48) | KMT2ASMN1; SMN2MEN1MAPTMAPK1 | |
| Bromide SCHEMBL28845552 | 0.96 | RAD52 (0.48) | KMT2ASMN1; SMN2MEN1MAPTMAPK1 | |
| Bromide SCHEMBL28779518 | 0.96 | CHRM2 (0.45) | KMT2ASMN1; SMN2MEN1MAPTMAPK1 | |
| SCHEMBL27656272 | 0.96 | CHRM2 (0.43) | KMT2ASMN1; SMN2MEN1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9631045-B2 | Polycarbodiimides having onium salt groups | PPG INDUSTRIES OHIO, INC. (US) | 2017-04-25 | — | — | US | disclosed |
| US-8981005-B2 | Coating compositions that include onium salt group containing polycarbodiimides | PPG INDUSTRIES OHIO, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| WO-2014099923-A1 | IMPROVED ANTIMICROBIAL EFFECTS IN POLYMERS | BASF SE (DE) | 2014-06-26 | — | — | WO | disclosed |
| US-20140170238-A1 | Antimicrobial effects in polymers | BASF SE (DE) | 2014-06-19 | — | — | US | disclosed |
| US-8258202-B2 | Antimicrobial coating compositions, related coatings and coated substrates | PPG INDUSTRIES OHIO, INC (US) | 2012-09-04 | — | — | US | disclosed |
| WO-2010093536-A1 | POLYCARBODIIMIDES HAVING ONIUM SALT GROUPS | PPG INDUSTRIES OHIO, INC. (US) | 2010-08-19 | — | — | WO | disclosed |
| US-20100204515-A1 | POLYCARBODIIMIDES HAVING ONIUM SALT GROUPS | PPG INDUSTRIES OHIO, INC. (US) | 2010-08-12 | — | — | US | disclosed |
| US-20100204414-A1 | COATING COMPOSITIONS THAT INCLUDE ONIUM SALT GROUP CONTAINING POLYCARBODIIMIDES | PPG INDUSTRIES OHIO, INC. (US) | 2010-08-12 | — | — | US | disclosed |
| US-20100204357-A1 | ANTIMICROBIAL COATING COMPOSITIONS, RELATED COATINGS AND COATED SUBSTRATES | PPG INDUSTRIES OHIO, INC. (US) | 2010-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204515-A1 | POLYCARBODIIMIDES HAVING ONIUM SALT GROUPS | CA7, HDAC6, HDAC10 | CHRM2 3505/4885CHRM1 3852/4885ACHE 3551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.