Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 18/20 | 0.48 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.31 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30289499 | 0.92 | CRBN (0.51) | CRBNDDB1GSPT1 | |
| SCHEMBL30289299 | 0.90 | CRBN (0.52) | CRBNDDB1 | |
| SCHEMBL30289100 | 0.86 | CRBN (0.50) | CRBNDDB1GSPT1 | |
| SCHEMBL30289502 | 0.86 | CRBN (0.51) | CRBNDDB1GSPT1 | |
| SCHEMBL30289153 | 0.86 | CRBN (0.51) | CRBNDDB1GSPT1 | |
| SCHEMBL30288911 | 0.85 | CRBN (0.50) | CRBNDDB1GSPT1HRH2HRH1 | |
| SCHEMBL30289241 | 0.85 | CRBN (0.50) | CRBNDDB1GSPT1HRH2HRH1 | |
| SCHEMBL30289322 | 0.85 | CRBN (0.50) | CRBNDDB1GSPT1HRH2HRH1 | |
| SCHEMBL30289130 | 0.84 | CRBN (0.49) | CRBNDDB1GSPT1HRH2HRH1 | |
| SCHEMBL30289244 | 0.84 | CRBN (0.49) | CRBNDDB1GSPT1HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405359-A2 | MDM2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023049790-A2 | MDM2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-03-30 | — | — | WO | disclosed |