Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.52 |
| ▸ | DDB1 | Q16531 | 18/20 | 0.52 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.33 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30289499 | 0.93 | CRBN (0.51) | CRBNDDB1 | |
| SCHEMBL31217697 | 0.91 | CRBN (0.54) | CRBNDDB1IKZF3 | |
| SCHEMBL30289000 | 0.90 | CRBN (0.48) | CRBNDDB1 | |
| SCHEMBL30289100 | 0.87 | CRBN (0.50) | CRBNDDB1 | |
| SCHEMBL30289153 | 0.87 | CRBN (0.51) | CRBNDDB1 | |
| SCHEMBL30289502 | 0.87 | CRBN (0.51) | CRBNDDB1 | |
| SCHEMBL30289409 | 0.87 | DDB1 (0.44) | CRBNDDB1IKZF1 | |
| SCHEMBL21997585 | 0.86 | CRBN (0.58) | CRBNDDB1IKZF3 | |
| SCHEMBL30289241 | 0.86 | CRBN (0.50) | CRBNDDB1 | |
| SCHEMBL30289322 | 0.86 | CRBN (0.50) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405359-A2 | MDM2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023049790-A2 | MDM2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-03-30 | — | — | WO | disclosed |