Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 7/20 | 0.52 |
| ▸ | DDB1 | Q16531 | 6/20 | 0.52 |
| ▸ | IKZF2 | Q9UKS7 | 11/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23541317 | 0.93 | CRBN (0.52) | CRBNDDB1IKZF2OPRL1 | |
| SCHEMBL25036615 | 0.92 | DDB1 (0.58) | CRBNDDB1IKZF2 | |
| SCHEMBL30273456 | 0.92 | DDB1 (0.58) | CRBNDDB1IKZF2 | |
| SCHEMBL25036590 | 0.92 | DDB1 (0.58) | CRBNDDB1IKZF2 | |
| SCHEMBL29579470 | 0.89 | DDB1 (0.53) | CRBNDDB1IKZF2OPRL1 | |
| SCHEMBL31333960 | 0.88 | DDB1 (0.54) | CRBNDDB1IKZF2 | |
| SCHEMBL30289048 | 0.88 | DDB1 (0.47) | CRBNDDB1IKZF2OPRL1 | |
| SCHEMBL30289300 | 0.88 | CRBN (0.54) | CRBNDDB1IKZF2OPRL1 | |
| SCHEMBL24481077 | 0.87 | CRBN (0.55) | CRBNDDB1IKZF2 | |
| SCHEMBL29579648 | 0.87 | CRBN (0.55) | CRBNDDB1IKZF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405359-A2 | MDM2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023049790-A2 | MDM2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-03-30 | — | — | WO | disclosed |