Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 12/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 10/20 | 0.45 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.38 |
| ▸ | IRAK3 | Q9Y616 | 2/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.38 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.38 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.38 |
| ▸ | USP14 | P54578 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30289037 | 0.94 | DDB1 (0.46) | CRBNDDB1KCNA3USP14DRD2 | |
| SCHEMBL31281758 | 0.90 | CRBN (0.51) | CRBNDDB1DRD2PIK3CAMTOR | |
| SCHEMBL30289094 | 0.89 | DDB1 (0.45) | CRBNDDB1KCNA3DRD2PIK3CA | |
| SCHEMBL30289436 | 0.85 | CRBN (0.49) | CRBNDDB1IRAK1IRAK4IRAK3 | |
| SCHEMBL30289475 | 0.84 | DDB1 (0.56) | CRBNDDB1KCNA3DRD2PIK3CA | |
| SCHEMBL30288962 | 0.83 | DDB1 (0.49) | CRBNDDB1KCNA3DRD2PIK3CA | |
| SCHEMBL30289264 | 0.83 | DDB1 (0.57) | CRBNDDB1KCNA3DRD2PIK3CA | |
| SCHEMBL22835971 | 0.82 | DDB1 (0.55) | CRBNDDB1 | |
| SCHEMBL30768477 | 0.82 | DDB1 (0.55) | CRBNDDB1 | |
| SCHEMBL30768650 | 0.82 | DDB1 (0.55) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405359-A2 | MDM2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023049790-A2 | MDM2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-03-30 | — | — | WO | disclosed |