Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.54 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.54 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.54 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PREP | P48147 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3779343 | 1.00 | PDK1 (0.54) | PDK1PDK2PDK3PDK4PARP1 | |
| SCHEMBL21528003 | 0.97 | PDK1 (0.55) | PDK1PDK2PDK3PDK4PARP1 | |
| SCHEMBL21528001 | 0.97 | PDK1 (0.55) | PDK1PDK2PDK3PDK4PARP1 | |
| SCHEMBL15606326 | 0.95 | PARP1 (0.57) | PDK1PDK2PDK3PDK4PARP1 | |
| SCHEMBL4676650 | 0.95 | PDK1 (0.54) | PDK1PDK2PDK3PDK4PARP1 | |
| SCHEMBL30289174 | 0.95 | PARP1 (0.57) | PDK1PDK2PDK3PDK4PARP1 | |
| SCHEMBL15298945 | 0.93 | PDK1 (0.53) | PDK1PDK2PDK3PDK4PARP1 | |
| SCHEMBL6487540 | 0.93 | PDK1 (0.53) | PDK1PDK2PDK3PDK4PARP1 | |
| SCHEMBL1288345 | 0.93 | PDK1 (0.53) | PDK1PDK2PDK3PDK4PARP1 | |
| SCHEMBL4841744 | 0.92 | PDK1 (0.52) | PDK1PDK2PDK3PDK4PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405359-A2 | MDM2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023049790-A2 | MDM2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-03-30 | — | — | WO | disclosed |