Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 20/20 | 0.58 |
| ▸ | DDB1 | Q16531 | 19/20 | 0.58 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23842395 | 1.00 | CRBN (0.58) | CRBNDDB1GSPT1 | |
| SCHEMBL23832518 | 0.99 | CRBN (0.59) | CRBNDDB1GSPT1 | |
| SCHEMBL23832581 | 0.96 | CRBN (0.60) | CRBNDDB1GSPT1 | |
| SCHEMBL29347188 | 0.96 | CRBN (0.53) | CRBNDDB1GSPT1 | |
| SCHEMBL29347190 | 0.95 | CRBN (0.54) | CRBNDDB1GSPT1 | |
| SCHEMBL22526656 | 0.93 | CRBN (0.62) | CRBNDDB1GSPT1 | |
| SCHEMBL29651793 | 0.93 | CRBN (0.62) | CRBNDDB1GSPT1 | |
| SCHEMBL21070678 | 0.92 | CRBN (0.57) | CRBNDDB1GSPT1 | |
| SCHEMBL22526137 | 0.89 | DDB1 (0.58) | CRBNDDB1 | |
| SCHEMBL31601585 | 0.88 | CRBN (0.52) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405359-A2 | MDM2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023049790-A2 | MDM2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-03-30 | — | — | WO | disclosed |