Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | AKT2 | P31751 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.37 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.35 |
| ▸ | GRM8 | O00222 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21834045 | 0.76 | AKT2 (0.41) | AKT1AKT2AURKAAURKBINCENP | |
| SCHEMBL21193333 | 0.76 | KCNH2 (0.41) | AKT1AKT2AURKAAURKBINCENP | |
| SCHEMBL19240310 | 0.76 | AKT2 (0.41) | AKT1AKT2AURKAAURKBINCENP | |
| SCHEMBL23291933 | 0.76 | ALDH1A1 (0.51) | AKT1AKT2AURKAAURKBINCENP | |
| SCHEMBL30557225 | 0.76 | ALDH1A1 (0.51) | AKT1AKT2AURKAAURKBINCENP | |
| Hydrochloric Acid SCHEMBL32685351 | 0.74 | ALDH1A1 (0.50) | AKT1AKT2AURKAAURKBINCENP | |
| Hydrochloric Acid SCHEMBL30557160 | 0.74 | ALDH1A1 (0.50) | AKT1AKT2AURKAAURKBINCENP | |
| SCHEMBL30387828 | 0.73 | LRRK2 (0.38) | AKT1AKT2AURKAAURKBINCENP | |
| SCHEMBL28988096 | 0.73 | LRRK2 (0.38) | AKT1AKT2AURKAAURKBINCENP | |
| SCHEMBL19861999 | 0.72 | MAPK8 (0.38) | AKT1AKT2AURKAAURKBINCENP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4146641-A1 | SUBSTITUTED {5-METHOXY-6-[(5-METHOXYPYRIDIN-2-YL)METHOXY]PYRIDIN-3-YL}METHYL COMPOUNDS AS CSF-1R INHIBITORS | Eli Lilly and Company (US) | 2023-03-15 | — | — | EP | disclosed |