Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 5/20 | 0.46 |
| ▸ | CDK2 | P24941 | 5/20 | 0.46 |
| ▸ | CDK1 | P06493 | 3/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.44 |
| ▸ | CDK4 | P11802 | 2/20 | 0.43 |
| ▸ | CCND1 | P24385 | 2/20 | 0.43 |
| ▸ | CCND3 | P30281 | 2/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30291181 | 0.88 | CCNE1 (0.59) | CCNE1CDK2CDK1CCNB1LRRK2 | |
| SCHEMBL27225073 | 0.88 | CCNE1 (0.59) | CCNE1CDK2CDK1CCNB1LRRK2 | |
| SCHEMBL22900922 | 0.74 | CCNE1 (0.59) | CCNE1CDK2CDK1CCNB1LRRK2 | |
| SCHEMBL30291164 | 0.74 | CCNE1 (0.37) | CCNE1CDK2CDK1CCNB1LRRK2 | |
| SCHEMBL16205608 | 0.69 | MTOR (0.37) | PIK3CAMTOR | |
| SCHEMBL30919959 | 0.68 | KIT (0.42) | CCNE1CDK2CDK1CCNB1KIT | |
| SCHEMBL30291343 | 0.68 | CCNE1 (0.55) | CCNE1CDK2CDK1CCNB1LRRK2 | |
| SCHEMBL30291204 | 0.68 | JAK2 (0.40) | CCNE1CDK2CDK1CCNB1LRRK2 | |
| SCHEMBL30291151 | 0.68 | JAK2 (0.40) | CCNE1CDK2CDK1CCNB1LRRK2 | |
| SCHEMBL30291203 | 0.68 | JAK2 (0.40) | CCNE1CDK2CDK1CCNB1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4355742-A1 | SUBSTITUTED PYRIMIDINYL-PYRAZOLES AS CDK2 INHIBITORS | Blueprint Medicines Corporation (US) | 2024-04-24 | — | — | EP | disclosed |
| CN-117813300-A | Substituted pyrimidinyl-pyrazoles as CDK2 inhibitors | 缆图药品公司 | 2024-04-02 | — | — | CN | disclosed |
| WO-2022266190-A1 | SUBSTITUTED PYRIMIDINYL-PYRAZOLES AS CDK2 INHIBITORS | BLUEPRINT MEDICINES CORPORATION (US) | 2022-12-22 | — | — | WO | disclosed |