Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.68 |
| ▸ | ROCK2 | O75116 | 10/20 | 0.56 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.51 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30292044 | 1.00 | MAOB (0.68) | MAOBROCK2IMPDH2IMPDH1RPS6KB1 | |
| SCHEMBL22165399 | 1.00 | MAOB (0.68) | MAOBROCK2IMPDH2IMPDH1RPS6KB1 | |
| SCHEMBL26527898 | 0.90 | ROCK2 (0.59) | MAOBROCK2IMPDH2IMPDH1AAK1 | |
| SCHEMBL22158349 | 0.89 | ROCK2 (0.58) | MAOBROCK2IMPDH2IMPDH1RPS6KB1 | |
| SCHEMBL22158319 | 0.89 | MAOB (0.68) | MAOBROCK2IMPDH2IMPDH1RPS6KB1 | |
| SCHEMBL29454982 | 0.89 | MAOB (0.68) | MAOBROCK2IMPDH2IMPDH1RPS6KB1 | |
| SCHEMBL30292035 | 0.89 | ROCK2 (0.58) | MAOBROCK2IMPDH2IMPDH1RPS6KB1 | |
| SCHEMBL30292055 | 0.89 | MAOB (0.68) | MAOBROCK2IMPDH2IMPDH1RPS6KB1 | |
| SCHEMBL22158355 | 0.88 | ROCK2 (0.71) | MAOBROCK2IMPDH2IMPDH1AAK1 | |
| SCHEMBL30292024 | 0.88 | ROCK2 (0.71) | MAOBROCK2IMPDH2IMPDH1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113227086-B | N- (4- (oxazol-5-yl) phenyl) chroman-3-carboxamide derivatives and related compounds as stimulators of production of retinal precursor cells for the treatment of neuroretinal disorders | 内生疗法公司 | 2024-07-26 | — | — | CN | disclosed |
| EP-4167999-A1 | NEW COMPOUNDS AND THEIR USE AS THERAPEUTICALLY ACTIVE SUBSTANCES IN THE TREATMENT AND/OR PREVENTION OF DISEASES INVOLVING THE RETINAL PIGMENT EPITHELIUM | Endogena Therapeutics, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |
| CN-115916192-A | Novel compounds and their use as therapeutically active substances for the treatment and/or prophylaxis of diseases in which the retinal pigment epithelium is involved | 内生疗法公司 | 2023-04-04 | — | — | CN | disclosed |