SCHEMBL30293241

SCHEMBL30293241

COc1ccc(COc2ccc3c(c2)CC(CCI)C(=O)N3Cc2ccc(OC)cc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 2/20 0.41
CMA1 P23946 1/20 0.40
SRD5A1 P18405 1/20 0.39
GSK3A P49840 1/20 0.39
GSK3B P49841 1/20 0.39
CHRM5 P08912 1/20 0.39
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA9 Q16790 1/20 0.39
SPHK2 Q9NRA0 1/20 0.38
ENPP2 Q13822 1/20 0.38
HRH3 Q9Y5N1 1/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
PARK7 Q99497 1/20 0.38
XIAP P98170 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28978974 1.00 PTPN1 (0.41) PTPN1CMA1SRD5A1GSK3AGSK3B
SCHEMBL30293238 0.91 CHRM5 (0.41) PTPN1CMA1SRD5A1GSK3AGSK3B
SCHEMBL28978976 0.91 CHRM5 (0.41) PTPN1CMA1SRD5A1GSK3AGSK3B
SCHEMBL31398270 0.87 MAPT (0.43) CMA1GSK3AGSK3BPARK7
SCHEMBL30100771 0.84 L3MBTL1 (0.49) CMA1GSK3AGSK3B
SCHEMBL16163178 0.84 L3MBTL1 (0.49) CMA1GSK3AGSK3B
SCHEMBL28979244 0.78 SRD5A1 (0.49) PTPN1CMA1SRD5A1GSK3AGSK3B
SCHEMBL31398281 0.77 POLB (0.45) CMA1GSK3AGSK3BCHRM5PARK7
SCHEMBL16163298 0.77 L3MBTL1 (0.47) CMA1GSK3AGSK3B
SCHEMBL31515395 0.77 L3MBTL1 (0.48) CMA1GSK3AGSK3BRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109988093-B Amine compound for inhibiting SSAO/VAP-1 and application thereof in medicine 广东东阳光药业有限公司 2023-04-07 CN disclosed