Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.51 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.51 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.51 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.51 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | GALR2 | O43603 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3027084 | 0.94 | ALDH1A1 (0.52) | ALDH1A1KDM4EHTTPSEN1PSEN2 | |
| SCHEMBL8140836 | 0.90 | PSEN1 (0.51) | ALDH1A1KDM4EHTTPSEN1PSEN2 | |
| SCHEMBL3027723 | 0.90 | PSEN1 (0.53) | ALDH1A1KDM4EHTTPSEN1PSEN2 | |
| SCHEMBL3023884 | 0.89 | PSEN1 (0.55) | ALDH1A1KDM4EHTTPSEN1PSEN2 | |
| SCHEMBL3028270 | 0.87 | PSEN1 (0.51) | ALDH1A1KDM4EHTTPSEN1PSEN2 | |
| SCHEMBL3028303 | 0.85 | PSEN1 (0.46) | ALDH1A1KDM4EHTTPSEN1PSEN2 | |
| SCHEMBL3017235 | 0.84 | PSEN1 (0.52) | ALDH1A1KDM4EHTTPSEN1PSEN2 | |
| SCHEMBL3028320 | 0.82 | PSEN1 (0.45) | ALDH1A1KDM4EHTTPSEN1PSEN2 | |
| SCHEMBL8141028 | 0.81 | PSEN1 (0.52) | ALDH1A1KDM4EHTTPSEN1PSEN2 | |
| SCHEMBL3023365 | 0.80 | PSEN1 (0.56) | ALDH1A1KDM4EHTTPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100204230-A1 | PIPERAZINE DERIVATIVES FOR TREATMENT OF AD AND RELATED CONDITIONS | MERCK SHARP & DOHME CORP. | 2010-08-12 | — | — | US | disclosed |
| US-20100204230-A1 | PIPERAZINE DERIVATIVES FOR TREATMENT OF AD AND RELATED CONDITIONS | MERCK SHARP & DOHME CORP. | 2010-08-12 | — | — | US | disclosed |
| US-20100204230-A1 | PIPERAZINE DERIVATIVES FOR TREATMENT OF AD AND RELATED CONDITIONS | MERCK SHARP & DOHME CORP. | 2010-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204230-A1 | PIPERAZINE DERIVATIVES FOR TREATMENT OF AD AND RELATED CONDITIONS | PSEN1, PSEN2, APP | ALDH1A1 384/4885KDM4E 3421/4885HTT 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.