Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24035319 | 0.86 | HDAC1 (0.38) | MAPTHDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL29064981 | 0.85 | MAPT (0.39) | MAPTHTTLMNACNR1 | |
| SCHEMBL30177452 | 0.85 | MAPT (0.41) | MAPTHTTHDAC1HDAC8HDAC6 | |
| SCHEMBL30295688 | 0.83 | MAPT (0.44) | MAPTHTTLMNA | |
| SCHEMBL24036171 | 0.83 | HDAC1 (0.41) | MAPTHDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL24035799 | 0.83 | CNR1 (0.37) | HDAC1HDAC8HDAC6HDAC5CNR1 | |
| SCHEMBL30295747 | 0.83 | MAPT (0.45) | MAPTHTTALDH1A1LMNA | |
| SCHEMBL24035163 | 0.83 | LMNA (0.36) | HDAC1HDAC8HDAC6HDAC5LMNA | |
| SCHEMBL26735363 | 0.82 | HDAC2 (0.36) | MAPTHTTHDAC1HDAC8ALDH1A1 | |
| SCHEMBL30177509 | 0.82 | MAPT (0.43) | MAPTHTTHDAC1HDAC8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4149459-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT P53 FUNCTION | PMV Pharmaceuticals, Inc. (US) | 2023-03-22 | — | — | EP | disclosed |