Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 3/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.35 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30295962 | 0.84 | ACACB (0.33) | PDE4B | |
| SCHEMBL30295996 | 0.84 | ALDH1A1 (0.33) | MAPK1 | |
| SCHEMBL30296200 | 0.80 | ALDH1A1 (0.35) | MAPK1 | |
| SCHEMBL30295953 | 0.78 | ALDH1A1 (0.34) | MAPK1 | |
| SCHEMBL30295883 | 0.72 | — | — | |
| SCHEMBL19785520 | 0.70 | CYP3A4 (0.39) | MERTKFLT3TYRO3GAS6AXL | |
| SCHEMBL29041445 | 0.68 | LRRK2 (0.36) | MERTKFLT3TYRO3GAS6AXL | |
| SCHEMBL30111146 | 0.58 | MAPK1 (0.43) | MERTKFLT3TYRO3GAS6AXL | |
| SCHEMBL29501995 | 0.56 | PDE4B (0.58) | MERTKFLT3TYRO3GAS6AXL | |
| SCHEMBL20299423 | 0.56 | PDE4B (0.58) | MERTKFLT3TYRO3GAS6AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116478131-A | 2, 5-disubstituted and 2,5, 6-trisubstituted 3-methylpyrazines as allosteric SHP2 inhibitors | 锐新医药公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-116478132-A | 2, 5-disubstituted and 2,5, 6-trisubstituted 3-methylpyrazines as allosteric SHP2 inhibitors | 锐新医药公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-109983001-B | 2, 5-disubstituted 3-methylpyrazines and 2,5, 6-trisubstituted 3-methylpyrazines as allosteric SHP2 inhibitors | 锐新医药公司 | 2023-04-04 | — | — | CN | disclosed |