Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK4 | Q13043 | 5/20 | 0.53 |
| ▸ | STK3 | Q13188 | 5/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 3/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | ABL2 | P42684 | 1/20 | 0.37 |
| ▸ | ADK | P55263 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30295914 | 0.92 | STK4 (0.54) | STK4STK3LRRK2TP53LMNA | |
| SCHEMBL30295798 | 0.86 | STK4 (0.56) | STK4STK3LRRK2TP53LMNA | |
| SCHEMBL30295768 | 0.86 | STK4 (0.45) | STK4STK3LRRK2TP53LMNA | |
| SCHEMBL30295858 | 0.85 | STK4 (0.55) | STK4STK3LRRK2TP53LMNA | |
| SCHEMBL30295700 | 0.84 | SRC (0.42) | STK4STK3LRRK2TP53LMNA | |
| SCHEMBL31301813 | 0.83 | STK4 (0.44) | STK4STK3LRRK2TP53LMNA | |
| SCHEMBL30295881 | 0.80 | STK4 (0.44) | STK4STK3LRRK2TP53LMNA | |
| SCHEMBL30295820 | 0.80 | LMNA (0.49) | STK4STK3LRRK2TP53LMNA | |
| SCHEMBL30295902 | 0.78 | STK4 (0.44) | STK4STK3LRRK2TP53LMNA | |
| SCHEMBL30295809 | 0.78 | LMNA (0.46) | STK4STK3LRRK2TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023055731-A1 | INHIBITORS OF SERINE/THREONINE PROTEIN KINASE STK3 OR STK4 AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2023-04-06 | — | — | WO | disclosed |