Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23362766 | 1.00 | SMN1; SMN2 (0.52) | SMN1; SMN2HSD17B10ALDH1A1GAAHPGD | |
| SCHEMBL3144672 | 0.88 | SMN1; SMN2 (0.51) | SMN1; SMN2CYP3A4CYP1A2CYP2C19CSNK1D | |
| SCHEMBL30296208 | 0.86 | ALDH1A1 (0.41) | SMN1; SMN2HSD17B10ALDH1A1GAAHPGD | |
| SCHEMBL23362831 | 0.86 | ALDH1A1 (0.41) | SMN1; SMN2HSD17B10ALDH1A1GAAHPGD | |
| SCHEMBL6343901 | 0.85 | DPP4 (0.47) | SMN1; SMN2HSD17B10ALDH1A1GAAHPGD | |
| SCHEMBL6343545 | 0.84 | HSD17B10 (0.70) | SMN1; SMN2HSD17B10ALDH1A1GAAMEN1 | |
| SCHEMBL29431167 | 0.84 | HSD17B10 (0.70) | SMN1; SMN2HSD17B10ALDH1A1GAAMEN1 | |
| SCHEMBL8063678 | 0.84 | MAPK8 (0.46) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL10864128 | 0.84 | CYP3A4 (0.62) | SMN1; SMN2HSD17B10ALDH1A1GAAHPGD | |
| SCHEMBL24713929 | 0.83 | SMN1; SMN2 (0.57) | SMN1; SMN2HSD17B10ALDH1A1GAACSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115811977-A | Allosteric EGFR inhibitors and methods of use thereof | 达纳-法伯癌症研究所股份有限公司 | 2023-03-17 | — | — | CN | disclosed |