Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 2/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | INPPL1 | O15357 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26091993 | 1.00 | NQO2 (0.48) | NQO2ADORA2BCYP11B2CYP11B1CYP17A1 | |
| SCHEMBL26469046 | 0.80 | CYP11B2 (0.43) | NQO2ADORA2BCYP11B2CYP11B1CYP17A1 | |
| SCHEMBL30296491 | 0.80 | CYP11B2 (0.43) | NQO2ADORA2BCYP11B2CYP11B1CYP17A1 | |
| SCHEMBL30296225 | 0.73 | CYP11B2 (0.45) | ADORA2BCYP11B2CYP11B1CYP3A4ALOX5AP | |
| SCHEMBL26922914 | 0.73 | CYP11B2 (0.44) | NQO2ADORA2BCYP11B2CYP11B1CYP17A1 | |
| SCHEMBL26459039 | 0.73 | CYP11B2 (0.45) | ADORA2BCYP11B2CYP11B1CYP3A4ALOX5AP | |
| SCHEMBL31512065 | 0.73 | CYP11B1 (0.50) | CYP11B2CYP11B1ALOX5APFEN1PIK3CD | |
| SCHEMBL15301520 | 0.72 | CYP11B2 (0.39) | NQO2ADORA2BCYP11B2CYP11B1CYP17A1 | |
| SCHEMBL16826172 | 0.70 | PIK3CD (0.51) | NQO2ADORA2BCYP11B2CYP11B1FEN1 | |
| SCHEMBL16826128 | 0.70 | PIM1 (0.48) | NQO2ADORA2BALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4419203-A1 | TRICYCLIC GPR65 MODULATORS | Pathios Therapeutics Limited (GB) | 2024-08-28 | — | — | EP | disclosed |
| CN-118451080-A | Tricyclic GPR65 modulators | 帕蒂奥斯治疗有限公司 | 2024-08-06 | — | — | CN | disclosed |
| WO-2023067322-A1 | TRICYCLIC GPR65 MODULATORS | Pathios Therapeutics Limited (GB) | 2023-04-27 | — | — | WO | disclosed |