SCHEMBL30298786

SCHEMBL30298786

CCOc1cc(-c2cc(C(=O)N3CC[C@H](C(=O)OC)CC34CC4)n[nH]2)c(F)cn1

nearest known ligand 0.32

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ ACACB O00763 2/20 0.32
▸ PRKCB P05771 1/20 0.32
▸ FFAR4 Q5NUL3 1/20 0.31
▸ KDM5A P29375 2/20 0.30
▸ TBK1 Q9UHD2 1/20 0.30
▸ NPC1 O15118 1/20 0.30
▸ RAB9A P51151 1/20 0.30
▸ MEN1 O00255 1/20 0.30
▸ KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24424524 0.93 FFAR4 (0.37) FFAR4KDM5ATBK1
SCHEMBL29584891 0.93 FFAR4 (0.37) FFAR4KDM5ATBK1
SCHEMBL29586245 0.93 FFAR4 (0.37) FFAR4KDM5ATBK1
SCHEMBL24424523 0.93 FFAR4 (0.37) FFAR4KDM5ATBK1
SCHEMBL29585040 0.93 FFAR4 (0.37) FFAR4KDM5ATBK1
SCHEMBL24423911 0.93 FFAR4 (0.37) FFAR4KDM5ATBK1
SCHEMBL30298816 0.91 KDM5A (0.31) ACACBPRKCBFFAR4KDM5A
SCHEMBL24423697 0.89 TLR8 (0.33) KDM5ATBK1
SCHEMBL24423698 0.89 TLR8 (0.33) KDM5ATBK1
SCHEMBL24423699 0.89 TLR8 (0.33) KDM5ATBK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12606541-B2 PPARg modulators and methods of use EISAI R&D MANAGEMENT CO., LTD. (JP) 2026-04-21 — — US disclosed
US-20230062861-A1 PPARg MODULATORS AND METHODS OF USE EISAI R&D MANAGEMENT CO., LTD. (JP) 2023-03-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230062861-A1 PPARg MODULATORS AND METHODS OF USE PPARG, PPARA, PPARD ACACB 386/4885PRKCB 327/4885FFAR4 25/4885
US-12606541-B2 PPARg modulators and methods of use PPARG, PPARA, PPARD ACACB 440/4885PRKCB 433/4885FFAR4 69/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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