Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.72 |
| ▸ | ALK | Q9UM73 | 17/20 | 0.70 |
| ▸ | INSR | P06213 | 16/20 | 0.70 |
| ▸ | IGF1R | P08069 | 11/20 | 0.70 |
| ▸ | AURKA | O14965 | 3/20 | 0.70 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.70 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.54 |
| ▸ | PRKCG | P05129 | 1/20 | 0.54 |
| ▸ | ROS1 | P08922 | 1/20 | 0.54 |
| ▸ | FER | P16591 | 1/20 | 0.54 |
| ▸ | LTK | P29376 | 1/20 | 0.54 |
| ▸ | WEE1 | P30291 | 1/20 | 0.54 |
| ▸ | FRK | P42685 | 1/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
| ▸ | MST1R | Q04912 | 1/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.54 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.54 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.54 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30304319 | 0.92 | NTRK1 (0.69) | NTRK1ALKINSRIGF1RAURKA | |
| SCHEMBL3512908 | 0.91 | NTRK1 (0.72) | NTRK1ALKINSRIGF1RAURKA | |
| SCHEMBL30304596 | 0.90 | NTRK1 (0.71) | NTRK1ALKINSRIGF1RAURKA | |
| SCHEMBL30304737 | 0.89 | NTRK1 (0.68) | NTRK1ALKINSRIGF1RAURKA | |
| SCHEMBL3511638 | 0.89 | ALK (0.69) | NTRK1ALKINSRIGF1RAURKA | |
| SCHEMBL30304648 | 0.89 | NTRK1 (0.68) | NTRK1ALKINSRIGF1RAURKA | |
| SCHEMBL30304401 | 0.87 | ALK (0.67) | NTRK1ALKINSRIGF1RAURKA | |
| SCHEMBL25401224 | 0.83 | ALK (0.82) | NTRK1ALKINSRIGF1RAURKA | |
| SCHEMBL3511212 | 0.83 | ALK (1.00) | NTRK1ALKINSRIGF1RAURKA | |
| SCHEMBL28917625 | 0.83 | INSR (0.68) | NTRK1ALKINSRIGF1RAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023055952-A1 | NEUROTROPHIC TYROSINE RECEPTOR KINASE (NTRK) DEGRADING COMPOUNDS | C4 THERAPEUTICS, INC. (US) | 2023-04-06 | — | — | WO | disclosed |