Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 18/20 | 0.76 |
| ▸ | ALK | Q9UM73 | 18/20 | 0.76 |
| ▸ | IGF1R | P08069 | 14/20 | 0.76 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.74 |
| ▸ | AURKA | O14965 | 3/20 | 0.74 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.74 |
| ▸ | PLK4 | O00444 | 1/20 | 0.74 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.74 |
| ▸ | JAK2 | O60674 | 1/20 | 0.74 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.74 |
| ▸ | ABL1 | P00519 | 1/20 | 0.74 |
| ▸ | PRKCG | P05129 | 1/20 | 0.74 |
| ▸ | LCK | P06239 | 1/20 | 0.74 |
| ▸ | FYN | P06241 | 1/20 | 0.74 |
| ▸ | CSF1R | P07333 | 1/20 | 0.74 |
| ▸ | LYN | P07948 | 1/20 | 0.74 |
| ▸ | RET | P07949 | 1/20 | 0.74 |
| ▸ | MET | P08581 | 1/20 | 0.74 |
| ▸ | ROS1 | P08922 | 1/20 | 0.74 |
| ▸ | KIT | P10721 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21759420 | 0.90 | INSR (0.76) | INSRALKIGF1RNTRK1AURKA | |
| SCHEMBL25649763 | 0.90 | INSR (0.76) | INSRALKIGF1RNTRK1AURKA | |
| SCHEMBL30459188 | 0.89 | INSR (0.74) | INSRALKIGF1RNTRK1AURKA | |
| SCHEMBL29188392 | 0.89 | INSR (0.74) | INSRALKIGF1RNTRK1AURKA | |
| SCHEMBL3512032 | 0.88 | ALK (0.91) | INSRALKIGF1RNTRK1AURKA | |
| SCHEMBL3510435 | 0.87 | ALK (0.98) | INSRALKIGF1RNTRK1AURKA | |
| SCHEMBL3511692 | 0.87 | ALK (0.96) | INSRALKIGF1RNTRK1AURKA | |
| SCHEMBL25398877 | 0.87 | INSR (0.83) | INSRALKIGF1RNTRK1AURKA | |
| SCHEMBL30170727 | 0.87 | INSR (0.83) | INSRALKIGF1RNTRK1AURKA | |
| SCHEMBL3513299 | 0.86 | INSR (0.83) | INSRALKIGF1RNTRK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023055952-A1 | NEUROTROPHIC TYROSINE RECEPTOR KINASE (NTRK) DEGRADING COMPOUNDS | C4 THERAPEUTICS, INC. (US) | 2023-04-06 | — | — | WO | disclosed |