⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2103232 | 1.00 | — | — | |
| SCHEMBL1779485 | 1.00 | — | — | |
| SCHEMBL4800650 | 0.97 | TSHR (0.42) | — | |
| SCHEMBL6519587 | 0.97 | TSHR (0.42) | — | |
| SCHEMBL6468322 | 0.89 | TSHR (0.37) | — | |
| SCHEMBL6523128 | 0.80 | TSHR (0.34) | — | |
| SCHEMBL4297438 | 0.80 | SLC18A3 (0.40) | — | |
| SCHEMBL779515 | 0.78 | SLC18A3 (0.43) | — | |
| SCHEMBL1929909 | 0.77 | SLC18A3 (0.41) | — | |
| SCHEMBL17054528 | 0.73 | MAOB (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1498 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023212650-A1 | NEXT GENERATION DIPROVOCIMS THAT ACTIVATE THE INNATE AND ADAPTIVE IMMUNE RESPONSE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2023-11-02 | — | — | WO | claimed |
| US-20230279006-A1 | NOVEL COMPOUNDS AND METHODS FOR INCREASING KLOTHO GENE EXPRESSION | KLOTHO THERAPEUTICS, INC. | 2023-09-07 | — | — | US | claimed |
| CN-114605401-A | Oxygen-containing five-membered heterocyclic compound, synthesis method, pharmaceutical composition and application | 江南大学 | 2022-06-10 | — | — | CN | claimed |
| CN-114573575-A | Oxygen-containing five-membered heterocyclic compound, synthesis method, pharmaceutical composition and application | 江南大学 | 2022-06-03 | — | — | CN | claimed |
| CN-114516867-A | Oxygen-containing five-membered heterocyclic compound, synthesis method, pharmaceutical composition and application | 江南大学 | 2022-05-20 | — | — | CN | claimed |
| WO-2022011171-A1 | NOVEL COMPOUNDS AND METHODS FOR INCREASING KLOTHO GENE EXPRESSION | KLOTHO THERAPEUTICS, INC. (US) | 2022-01-13 | — | — | WO | claimed |
| EP-2970119-B1 | NOVEL INDOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME (US) | 2021-11-03 | — | — | EP | claimed |
| US-20210315992-A1 | ADJUVANT EFFECT OF THE TLR1/2 AGONIST DIPROVOCIM SYNERGIZES WITH CHECKPOINT-INHIBITING ANTIBODIES TO ELIMINATE DISEASE | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2021-10-14 | — | — | US | claimed |
| CN-109641878-B | DIPROVOCIM: effective TLR agonist | 斯克里普斯研究学院 | 2021-09-14 | — | — | CN | claimed |
| CN-113164445-A | Adjuvant effect of the TLR1/2 agonist diprocomim synergistically potentiates checkpoint inhibitory antibodies to eliminate disease | 得克萨斯系统大学评议会 | 2021-07-23 | — | — | CN | claimed |
| US-5849922-A | Preparation of substituted alkenoic acids | ELI LILLY AND COMPANY (US) | 1998-12-15 | — | — | US | claimed |
| US-5763621-A | Metalloproteinase inhibitors | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1998-06-09 | — | — | US | claimed |
| EP-0816361-A2 | Preparation of substituted alkenoic acids | ELI LILLY AND COMPANY (US) | 1998-01-07 | — | — | EP | claimed |
| EP-0811621-A2 | Carbamoyl substituted oxazoles as thromboxane receptor antagonists | ELI LILLY AND COMPANY (US) | 1997-12-10 | — | — | EP | claimed |
| EP-0777646-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-06-11 | — | — | EP | claimed |
| WO-1996006074-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1996-02-29 | — | — | WO | claimed |
| US-4983623-A | Prolyl endopeptidase inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-01-08 | — | — | US | claimed |
| EP-0320753-A2 | Derivatives of cyclic aminoacids, their preparation, compounds containing them, and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-06-21 | — | — | EP | claimed |
| EP-0035597-B1 | PHARMACEUTICAL PREPARATIONS | Röhm Pharma GmbH (DE) | 1984-08-01 | — | — | EP | claimed |
| EP-0035597-A2 | Pharmaceutical preparations | Röhm Pharma GmbH (DE) | 1981-09-16 | — | — | EP | claimed |