Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 4/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.49 |
| ▸ | HTR2A | P28223 | 5/20 | 0.49 |
| ▸ | HTR2C | P28335 | 5/20 | 0.49 |
| ▸ | HRH1 | P35367 | 5/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.49 |
| ▸ | DRD1 | P21728 | 5/20 | 0.49 |
| ▸ | DRD3 | P35462 | 5/20 | 0.49 |
| ▸ | HTR1A | P08908 | 4/20 | 0.49 |
| ▸ | HTR2B | P41595 | 4/20 | 0.49 |
| ▸ | DRD2 | P14416 | 4/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3036768 | 0.91 | CYP2D6 (0.48) | CYP2D6CYP2C19MAPTMAPK1MEN1 | |
| SCHEMBL3046215 | 0.87 | SETD7 (0.57) | CYP2D6CYP2C19MAPTMAPK1MEN1 | |
| SCHEMBL3037289 | 0.86 | CYP2D6 (0.49) | CYP2D6CYP2C19MAPTMAPK1MEN1 | |
| SCHEMBL3046588 | 0.85 | DRD2 (0.50) | CYP2D6CYP2C19MAPTMAPK1MEN1 | |
| SCHEMBL3044352 | 0.84 | MAPT (0.49) | CYP2D6CYP2C19MAPTMAPK1MEN1 | |
| Hydrochloric Acid SCHEMBL3779856 | 0.84 | SETD7 (0.51) | CYP2D6CYP2C19MAPTMAPK1MEN1 | |
| Hydrochloric Acid SCHEMBL3040912 | 0.83 | MAPT (0.48) | CYP2D6CYP2C19MAPTMAPK1MEN1 | |
| SCHEMBL3036793 | 0.83 | MAPT (0.48) | CYP2D6CYP2C19MAPTMAPK1MEN1 | |
| SCHEMBL3030487 | 0.83 | CYP2D6 (0.51) | CYP2D6CYP2C19MAPTMAPK1MEN1 | |
| SCHEMBL3046581 | 0.83 | KMT2A (0.48) | CYP2D6CYP2C19MAPTMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243778-B1 | PIPERIDINE DERIVATIVE | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 2014-10-29 | — | — | EP | disclosed |
| US-8377967-B2 | Piperidine derivative | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2013-02-19 | — | — | US | disclosed |
| US-20100331365-A1 | PIPERIDINE DERIVATIVE | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2010-12-30 | — | — | US | disclosed |
| EP-2243778-A1 | PIPERIDINE DERIVATIVE | Nippon Zoki Pharmaceutical Co., Ltd. (JP) | 2010-10-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331365-A1 | PIPERIDINE DERIVATIVE | HRH4, HRH3, HRH2 | CYP2D6 729/4885CYP2C19 721/4885MAPT 2217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.