Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23755181 | 1.00 | PIK3CA (0.47) | PIK3CAPIK3CBPIK3CDPIK3CGSMN1; SMN2 | |
| SCHEMBL23755418 | 0.91 | PIK3CA (0.47) | PIK3CAPIK3CBPIK3CDPIK3CGSMN1; SMN2 | |
| SCHEMBL23773622 | 0.90 | PIK3CA (0.43) | PIK3CAPIK3CBPIK3CDPIK3CGSMN1; SMN2 | |
| SCHEMBL30087489 | 0.89 | PIK3CA (0.46) | PIK3CAPIK3CBPIK3CDPIK3CGSMN1; SMN2 | |
| SCHEMBL30087415 | 0.89 | PIK3CA (0.46) | PIK3CAPIK3CBPIK3CDPIK3CGSMN1; SMN2 | |
| SCHEMBL23754964 | 0.89 | PIK3CA (0.46) | PIK3CAPIK3CBPIK3CDPIK3CGSMN1; SMN2 | |
| SCHEMBL23755420 | 0.89 | PIK3CA (0.46) | PIK3CAPIK3CBPIK3CDPIK3CGSMN1; SMN2 | |
| SCHEMBL23755443 | 0.89 | CRHBP (0.50) | PIK3CAPIK3CBPIK3CDPIK3CGSMN1; SMN2 | |
| SCHEMBL23755212 | 0.89 | PIK3CA (0.46) | PIK3CAPIK3CBPIK3CDPIK3CGSMN1; SMN2 | |
| SCHEMBL23986112 | 0.89 | CNR2 (0.44) | PIK3CAPIK3CBPIK3CDPIK3CGSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230135152-A1 | PIKFYVE KINASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230135152-A1 | PIKFYVE KINASE INHIBITORS | PIKFYVE, PIP5K1B, PIP5K1C | PIK3CA 9/4885PIK3CB 7/4885PIK3CD 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.