Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.68 |
| ▸ | CSF1R | P07333 | 1/20 | 0.62 |
| ▸ | SIK1 | P57059 | 1/20 | 0.62 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.62 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 12/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.35 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23978372 | 1.00 | SIK2 (0.68) | SIK2CSF1RSIK1SIK3LCK | |
| SCHEMBL23978120 | 0.85 | SIK2 (0.51) | SIK2CSF1RSIK1SIK3LCK | |
| SCHEMBL30309533 | 0.85 | SIK2 (0.51) | SIK2CSF1RSIK1SIK3LCK | |
| SCHEMBL30309511 | 0.83 | SIK2 (0.51) | SIK2CSF1RSIK1SIK3FGFR4 | |
| SCHEMBL25882388 | 0.83 | SIK2 (0.49) | SIK2CSF1RSIK1SIK3FGFR4 | |
| SCHEMBL23978178 | 0.83 | SIK2 (0.51) | SIK2CSF1RSIK1SIK3FGFR4 | |
| SCHEMBL30309560 | 0.83 | SIK2 (0.49) | SIK2CSF1RSIK1SIK3FGFR4 | |
| SCHEMBL21479327 | 0.81 | SIK2 (0.49) | SIK2CSF1RSIK1SIK3FGFR4 | |
| SCHEMBL29864908 | 0.81 | SIK2 (0.49) | SIK2CSF1RSIK1SIK3FGFR4 | |
| SCHEMBL21479238 | 0.81 | SIK2 (1.00) | SIK2CSF1RSIK1SIK3LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143191-A2 | BICYCLIC KINASE INHIBITORS AND USES THEREOF | iOmx Therapeutics AG (DE) | 2023-03-08 | — | — | EP | disclosed |