Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | FOS | P01100 | 3/20 | 0.48 |
| ▸ | JUN | P05412 | 3/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.48 |
| ▸ | RELA | Q04206 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23126623 | 1.00 | SYK (0.52) | SYKALDH1A1MAPK1HTTMAPT | |
| SCHEMBL20875448 | 0.89 | SYK (0.57) | SYKALDH1A1MAPK1HTTMAPT | |
| SCHEMBL25904913 | 0.87 | SYK (0.55) | SYKALDH1A1MAPK1HTTMAPT | |
| SCHEMBL23126549 | 0.86 | SYK (0.52) | SYKALDH1A1MAPK1HTTMAPT | |
| SCHEMBL25827991 | 0.85 | SYK (0.51) | SYKALDH1A1MAPK1HTTMAPT | |
| SCHEMBL20658731 | 0.85 | ALDH1A1 (0.62) | SYKALDH1A1MAPK1HTTMAPT | |
| SCHEMBL20875531 | 0.85 | SYK (0.52) | SYKALDH1A1MAPK1HTTMAPT | |
| SCHEMBL30421007 | 0.85 | SYK (0.52) | SYKALDH1A1MAPK1HTTMAPT | |
| SCHEMBL20875402 | 0.84 | ALDH1A1 (0.55) | SYKALDH1A1MAPK1HTTMAPT | |
| SCHEMBL30310734 | 0.84 | ALDH1A1 (0.55) | SYKALDH1A1MAPK1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115838375-A | Pyrimido-dihydro-pyrazolone derivative, pharmaceutically acceptable salt thereof, and preparation method and application thereof | 优领医药科技(香港)有限公司 | 2023-03-24 | — | — | CN | disclosed |