SCHEMBL30314652

SCHEMBL30314652

C[C@H](O)[C@H](C)n1nc(-c2cccc(OC(F)F)c2)c2ncc(C(=O)NC3(C)CS(=O)(=O)C3)cc21

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DGAT2 Q96PD7 19/20 0.53
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30314677 1.00 DGAT2 (0.53) DGAT2KMT2A
SCHEMBL30559993 1.00 DGAT2 (0.53) DGAT2KMT2A
SCHEMBL30314702 1.00 DGAT2 (0.53) DGAT2KMT2A
SCHEMBL24045175 1.00 DGAT2 (0.53) DGAT2KMT2A
SCHEMBL24045174 1.00 DGAT2 (0.53) DGAT2KMT2A
SCHEMBL24045172 1.00 DGAT2 (0.53) DGAT2KMT2A
SCHEMBL24045173 1.00 DGAT2 (0.53) DGAT2KMT2A
SCHEMBL24045081 1.00 DGAT2 (0.53) DGAT2KMT2A
SCHEMBL30314689 1.00 DGAT2 (0.53) DGAT2KMT2A
SCHEMBL24045002 0.93 DGAT2 (0.55) DGAT2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4153584-A1 NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS Merck Sharp & Dohme LLC (US) 2023-03-29 EP disclosed