Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 19/20 | 0.56 |
| ▸ | MDM4 | O15151 | 14/20 | 0.56 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30225606 | 0.89 | CRHBP (0.58) | MDM2MDM4CRHBPCRHR2 | |
| SCHEMBL30225589 | 0.89 | CRHBP (0.58) | MDM2MDM4CRHBPCRHR2 | |
| SCHEMBL2395864 | 0.89 | CRHBP (0.58) | MDM2MDM4CRHBPCRHR2 | |
| SCHEMBL2393838 | 0.89 | CRHBP (0.58) | MDM2MDM4CRHBPCRHR2 | |
| SCHEMBL30225612 | 0.89 | CRHBP (0.58) | MDM2MDM4CRHBPCRHR2 | |
| SCHEMBL23842064 | 0.89 | CRHBP (0.58) | MDM2MDM4CRHBPCRHR2 | |
| SCHEMBL15701400 | 0.84 | MDM2 (0.50) | MDM2MDM4CRHBPCRHR2 | |
| SCHEMBL15701402 | 0.84 | MDM2 (0.50) | MDM2MDM4CRHBPCRHR2 | |
| SCHEMBL12258915 | 0.84 | MDM2 (0.50) | MDM2MDM4CRHBPCRHR2 | |
| SCHEMBL10854785 | 0.80 | CRHBP (0.67) | MDM2MDM4CRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115776887-A | MDM2 degrading agents and uses thereof | 凯麦拉医疗公司 | 2023-03-10 | — | — | CN | disclosed |