Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.51 |
| ▸ | EGLN3 | Q9H6Z9 | 6/20 | 0.51 |
| ▸ | EGLN2 | Q96KS0 | 4/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.42 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL303114 | 0.80 | EGLN3 (0.59) | EGLN1EGLN3EGLN2MAPTHIF1A | |
| SCHEMBL29895409 | 0.80 | AKR1B1 (0.51) | EGLN1EGLN3EGLN2AKR1B1MAPT | |
| SCHEMBL3852035 | 0.80 | AKR1B1 (0.51) | EGLN1EGLN3EGLN2AKR1B1MAPT | |
| SCHEMBL29895408 | 0.80 | AKR1B1 (0.51) | EGLN1EGLN3EGLN2AKR1B1MAPT | |
| SCHEMBL3777720 | 0.77 | EGLN1 (0.83) | EGLN1EGLN3EGLN2 | |
| SCHEMBL4373002 | 0.73 | AKR1B1 (0.55) | EGLN1EGLN3EGLN2AKR1B1MAPT | |
| SCHEMBL12727347 | 0.73 | EGLN3 (0.59) | EGLN1EGLN3EGLN2HIF1A | |
| SCHEMBL3852224 | 0.70 | EGLN3 (0.54) | EGLN1EGLN3EGLN2AKR1B1HIF1A | |
| SCHEMBL1919902 | 0.69 | MAPT (0.43) | AKR1B1AKR1A1MAPT | |
| SCHEMBL12727354 | 0.69 | EGLN3 (0.61) | EGLN1EGLN3EGLN2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500850-A | — | — | 2012-01-12 | — | — | JP | claimed |
| US-20110144167-A1 | Prolyl Hydroxylase Inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2011-06-16 | — | — | US | claimed |
| EP-2326179-A1 | PROLYL HYDROXYLASE INHIBITORS | Smithkline Beecham Corporation (US) | 2011-06-01 | — | — | EP | claimed |
| WO-2010025087-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-03-04 | — | — | WO | claimed |
| US-20110144167-A1 | Prolyl Hydroxylase Inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2011-06-16 | — | — | US | disclosed |
| US-20110144167-A1 | Prolyl Hydroxylase Inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2011-06-16 | — | — | US | disclosed |
| US-20110144167-A1 | Prolyl Hydroxylase Inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2011-06-16 | — | — | US | disclosed |
| EP-2326179-A1 | PROLYL HYDROXYLASE INHIBITORS | Smithkline Beecham Corporation (US) | 2011-06-01 | — | — | EP | disclosed |
| WO-2010025087-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-03-04 | — | — | WO | disclosed |
| WO-2010025087-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144167-A1 | Prolyl Hydroxylase Inhibitors | HIF1AN, EGLN2, EGLN3 | EGLN1 6/4885EGLN3 3/4885EGLN2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.