Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 4/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26071716 | 1.00 | TSHR (0.42) | TSHRKMT2APOLBCYP1A2SMN1; SMN2 | |
| SCHEMBL29875213 | 0.86 | TSHR (0.39) | TSHRKMT2APOLBCYP1A2SMN1; SMN2 | |
| SCHEMBL11165259 | 0.86 | MAP2K4 (0.44) | TSHRKMT2APOLBCYP1A2SMN1; SMN2 | |
| SCHEMBL30319377 | 0.82 | KMT2A (0.38) | TSHRKMT2APOLBCYP1A2SMN1; SMN2 | |
| SCHEMBL26071341 | 0.81 | KMT2A (0.44) | KMT2APOLBCYP1A2SMN1; SMN2KDM4E | |
| SCHEMBL30319390 | 0.81 | KMT2A (0.44) | KMT2APOLBCYP1A2SMN1; SMN2KDM4E | |
| SCHEMBL29874776 | 0.80 | TSHR (0.39) | TSHRKMT2APOLBCYP1A2SMN1; SMN2 | |
| SCHEMBL13995824 | 0.78 | KDM4E (0.63) | TSHRKMT2APOLBCYP1A2SMN1; SMN2 | |
| SCHEMBL30319401 | 0.78 | KDM4E (0.63) | TSHRKMT2APOLBCYP1A2SMN1; SMN2 | |
| SCHEMBL11163941 | 0.78 | PARP1 (0.50) | TSHRKMT2APOLBCYP1A2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161905-A1 | SUBSTITUTED (PHTHALAZIN-1-YLMETHYL)UREAS, SUBSTITUTED N-(PHTHALAZIN-1-YLMETHYL)AMIDES, AND ANALOGUES THEREOF | Arbutus Biopharma Corporation (CA) | 2023-04-12 | — | — | EP | disclosed |