Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 3/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 2/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30319380 | 1.00 | POLB (0.34) | POLBTSHRPARP1ALPLAR | |
| SCHEMBL30319383 | 0.87 | TSHR (0.36) | POLBTSHRPARP1ARMEN1 | |
| SCHEMBL30319444 | 0.87 | TSHR (0.36) | POLBTSHRPARP1ARMEN1 | |
| SCHEMBL30319375 | 0.85 | POLB (0.37) | POLBTSHRPARP1 | |
| SCHEMBL24097324 | 0.82 | POLB (0.37) | POLBTSHRPARP1ARPRMT5 | |
| SCHEMBL30319328 | 0.82 | POLB (0.37) | POLBTSHRPARP1ARPRMT5 | |
| SCHEMBL30319342 | 0.82 | POLB (0.37) | POLBTSHRPARP1ARPRMT5 | |
| Hydrochloric Acid SCHEMBL30319325 | 0.81 | POLB (0.36) | POLBTSHRPARP1ARPRMT5 | |
| SCHEMBL30319362 | 0.80 | ALPL (0.38) | POLBTSHRPARP1ALPLHTT | |
| SCHEMBL30319330 | 0.80 | POLB (0.55) | POLBTSHRPARP1ARPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161905-A1 | SUBSTITUTED (PHTHALAZIN-1-YLMETHYL)UREAS, SUBSTITUTED N-(PHTHALAZIN-1-YLMETHYL)AMIDES, AND ANALOGUES THEREOF | Arbutus Biopharma Corporation (CA) | 2023-04-12 | — | — | EP | disclosed |