Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.52 |
| ▸ | BTK | Q06187 | 7/20 | 0.52 |
| ▸ | EGFR | P00533 | 13/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 12/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.50 |
| ▸ | PRKDC | P78527 | 12/20 | 0.50 |
| ▸ | ABL1 | P00519 | 11/20 | 0.50 |
| ▸ | HCK | P08631 | 11/20 | 0.50 |
| ▸ | SRC | P12931 | 11/20 | 0.50 |
| ▸ | KDR | P35968 | 11/20 | 0.50 |
| ▸ | MTOR | P42345 | 11/20 | 0.50 |
| ▸ | EPHB4 | P54760 | 10/20 | 0.50 |
| ▸ | PI4KB | Q9UBF8 | 9/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | LYN | P07948 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24096503 | 1.00 | PIK3CD (0.52) | PIK3CDBTKEGFRPIK3CAPIK3CB | |
| SCHEMBL27586507 | 0.84 | BTK (0.69) | PIK3CDBTKEGFRPIK3CAPIK3CB | |
| SCHEMBL30180719 | 0.82 | RIPK2 (0.62) | BTKEGFRPIK3CGABL1HCK | |
| SCHEMBL23966762 | 0.82 | RIPK2 (0.62) | BTKEGFRPIK3CGABL1HCK | |
| SCHEMBL24096758 | 0.80 | PIK3CD (0.69) | PIK3CDBTKEGFRPIK3CAPIK3CB | |
| SCHEMBL29998830 | 0.80 | PIK3CD (0.69) | PIK3CDBTKEGFRPIK3CAPIK3CB | |
| SCHEMBL24096712 | 0.80 | RET (0.45) | PIK3CDBTKEGFRPIK3CAPIK3CB | |
| SCHEMBL22944055 | 0.79 | RET (0.44) | PIK3CDBTKEGFRPIK3CAPIK3CB | |
| SCHEMBL20746345 | 0.79 | RET (0.44) | PIK3CDBTKEGFRPIK3CAPIK3CB | |
| SCHEMBL20744755 | 0.79 | JAK2 (0.45) | PIK3CDBTKEGFRPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116075513-A | Inhibitors of NEK7 kinase | 哈利亚治疗公司 | 2023-05-05 | — | — | CN | disclosed |
| EP-4161933-A1 | INHIBITORS OF NEK7 KINASE | Halia Therapeutics, Inc. (US) | 2023-04-12 | — | — | EP | disclosed |