Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | KIF11 | P52732 | 4/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | LPL | P06858 | 3/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28383719 | 1.00 | MAPT (0.46) | MAPTPKMKIF11IDO1MAPK1 | |
| SCHEMBL422134 | 0.92 | PDE3B (0.44) | MAPTPKMKIF11CYP1A2CYP2C9 | |
| SCHEMBL31243804 | 0.84 | AHR (0.49) | CYP1A2CYP11B1CYP11B2PDE3BPDE3A | |
| SCHEMBL454535 | 0.84 | AHR (0.49) | CYP1A2CYP11B1CYP11B2PDE3BPDE3A | |
| SCHEMBL17042127 | 0.80 | CA9 (0.50) | BACE1CYP11B1CYP11B2LPLLIPG | |
| SCHEMBL21382549 | 0.80 | KDM4E (0.43) | MAPTLPLLIPGROCK1CA1 | |
| SCHEMBL4158988 | 0.79 | LPL (0.44) | MAPK1BACE1LPLLIPGROCK1 | |
| SCHEMBL30284869 | 0.79 | LPL (0.44) | MAPK1BACE1LPLLIPGROCK1 | |
| SCHEMBL20612387 | 0.78 | BRD9 (0.39) | BACE1LPLLIPGPRMT5WDR77 | |
| SCHEMBL29984001 | 0.77 | MAOB (0.47) | MAPK1LPLLIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161936-A1 | LPA RECEPTOR ANTAGONISTS AND USES THEREOF | GILEAD SCIENCES, INC. (US) | 2023-04-12 | — | — | EP | disclosed |
| CN-115867556-A | LPA receptor antagonists and uses thereof | 吉利德科学公司 | 2023-03-28 | — | — | CN | disclosed |