Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.47 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | CKS1B | P61024 | 2/20 | 0.45 |
| ▸ | SKP1 | P63208 | 2/20 | 0.45 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22712289 | 1.00 | KIT (0.47) | KITSMARCA2SMARCA4PBRM1MAP4K4 | |
| SCHEMBL2366669 | 0.88 | KIT (0.47) | KITCKS1BSKP1SKP2PTPN11 | |
| SCHEMBL30323222 | 0.86 | KIT (0.48) | KITSMARCA2SMARCA4PBRM1MAP4K4 | |
| SCHEMBL908053 | 0.86 | RET (0.49) | KITCKS1BSKP1SKP2KDM4E | |
| SCHEMBL22712188 | 0.86 | KIT (0.48) | KITSMARCA2SMARCA4PBRM1MAP4K4 | |
| SCHEMBL20293622 | 0.86 | KIT (0.46) | KITMAP4K4CKS1BSKP1SKP2 | |
| SCHEMBL18837988 | 0.85 | MEN1 (0.53) | KITCKS1BSKP1SKP2GPR119 | |
| SCHEMBL111360 | 0.85 | KIT (0.47) | KITSMARCA2SMARCA4PBRM1MAP4K4 | |
| SCHEMBL9999452 | 0.85 | GPR119 (0.50) | KITCKS1BSKP1SKP2GPR119 | |
| SCHEMBL15599325 | 0.84 | TLR9 (0.50) | KITCKS1BSKP1SKP2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110520127-B | Piperidinyl-substituted and piperazinyl-substituted heteroaromatic carboxamides as modulators of GPR6 | 武田药品工业株式会社 | 2023-05-16 | — | — | CN | disclosed |