Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | STS | P08842 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15804379 | 1.00 | NPC1 (0.43) | NPC1ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL5705691 | 0.88 | MAPT (0.52) | NPC1ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL15262320 | 0.88 | NPC1 (0.41) | NPC1ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL5221292 | 0.86 | MEN1 (0.49) | NPC1ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL15804381 | 0.85 | SLC6A2 (0.52) | NPC1ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL22265989 | 0.84 | STS (0.47) | NPC1ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL20164090 | 0.82 | DPP4 (0.45) | NPC1ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL16225130 | 0.82 | ESR2 (0.44) | NPC1ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL15804385 | 0.82 | STS (0.39) | NPC1ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL15804380 | 0.81 | SLC6A2 (0.55) | NPC1ALDH1A1MAPTMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2754653-B1 | AZETIDINE DERIVATIVE AND ANTIDEPRESSANT COMPOSITION CONTAINING SAME | KOREA INST SCI & TECH (KR) | 2016-11-09 | — | — | EP | disclosed |
| US-9120771-B2 | Azetidine derivative and antidepressant composition including the same | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2015-09-01 | — | — | US | disclosed |
| US-9120771-B2 | Azetidine derivative and antidepressant composition including the same | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2015-09-01 | — | — | US | disclosed |
| US-20140171402-A1 | AZETIDINE DERIVATIVE AND ANTIDEPRESSANT COMPOSITION INCLUDING THE SAME | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-06-19 | — | — | US | disclosed |
| US-20140171402-A1 | AZETIDINE DERIVATIVE AND ANTIDEPRESSANT COMPOSITION INCLUDING THE SAME | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-06-19 | — | — | US | disclosed |
| US-20100210617-A1 | Aryl-Alkylamines And Heteroaryl-Alkylamines As Protein Kinase Inhibitors | ASTEX THERAPEUTICS LIMITED (GB) | 2010-08-19 | — | — | US | disclosed |
| US-20100210617-A1 | Aryl-Alkylamines And Heteroaryl-Alkylamines As Protein Kinase Inhibitors | ASTEX THERAPEUTICS LIMITED (GB) | 2010-08-19 | — | — | US | disclosed |
| US-20100210617-A1 | Aryl-Alkylamines And Heteroaryl-Alkylamines As Protein Kinase Inhibitors | ASTEX THERAPEUTICS LIMITED (GB) | 2010-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140171402-A1 | AZETIDINE DERIVATIVE AND ANTIDEPRESSANT COMPOSITION INCLUDING THE SAME | SLC6A2, SLC6A3, SLC6A4 | NPC1 833/4885ALDH1A1 985/4885MAPT 424/4885 |
| US-20100210617-A1 | Aryl-Alkylamines And Heteroaryl-Alkylamines As Protein Kinase Inhibitors | ERBB2, ABL1, GRK2 | NPC1 3338/4885ALDH1A1 4220/4885MAPT 1601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.