Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 5/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | USP1 | O94782 | 1/20 | 0.36 |
| ▸ | SPR | P35270 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30327913 | 0.83 | ACACB (0.42) | ACACBSYKCYP11B2USP1SPR | |
| SCHEMBL30328964 | 0.83 | HRH3 (0.47) | HRH3USP30ACACBSYKPIK3CA | |
| SCHEMBL30327982 | 0.81 | USP30 (0.45) | HRH3USP30SYKHDAC4TACR1 | |
| Hydrochloric Acid SCHEMBL30328975 | 0.79 | TYK2 (0.41) | HRH3 | |
| SCHEMBL30328647 | 0.79 | CYP11B2 (0.50) | ACACBCYP11B2PIK3R1PIK3CASPR | |
| SCHEMBL30328394 | 0.78 | HRH3 (0.50) | HRH3USP30SYKTACR1 | |
| SCHEMBL30328457 | 0.77 | MEN1 (0.52) | HRH3USP30TACR1 | |
| SCHEMBL30327732 | 0.77 | TRPV1 (0.48) | HRH3USP30 | |
| SCHEMBL30328534 | 0.77 | HRH3 (0.51) | HRH3USP30ACACBPIK3CAHDAC4 | |
| SCHEMBL30328507 | 0.76 | USP30 (0.44) | HRH3USP30ACACBCYP11B2HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415706-A1 | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF | Vanqua Bio, Inc. (US) | 2024-08-21 | — | — | EP | disclosed |
| WO-2023064343-A1 | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF | VANQUA BIO, INC. (US) | 2023-04-20 | — | — | WO | disclosed |