Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | DTYMK | P23919 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30328454 | 0.83 | TSHR (0.40) | POLBOPRM1SIGMAR1KCNH2DTYMK | |
| SCHEMBL30327747 | 0.81 | HSD17B10 (0.47) | POLBCYP11B2GPR119EIF2AK4 | |
| SCHEMBL550592 | 0.81 | USP30 (0.57) | USP30HRH3CYP11B2MAPTHDAC1 | |
| SCHEMBL30328340 | 0.80 | USP30 (0.50) | USP30HRH3MKNK1MAPTEIF2AK4 | |
| SCHEMBL25164950 | 0.79 | HSD17B10 (0.53) | CYP11B2EIF2AK4 | |
| SCHEMBL30328325 | 0.79 | USP30 (0.54) | USP30HRH3OPRM1SIGMAR1CYP11B2 | |
| SCHEMBL5424968 | 0.78 | USP30 (0.74) | USP30HRH3CYP11B2GPR119 | |
| SCHEMBL30329126 | 0.77 | TSHR (0.48) | CYP11B2EIF2AK4 | |
| SCHEMBL30328864 | 0.77 | EIF2AK4 (0.51) | POLBCYP11B2GPR119EIF2AK4 | |
| SCHEMBL30327732 | 0.76 | TRPV1 (0.48) | USP30HRH3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415706-A1 | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF | Vanqua Bio, Inc. (US) | 2024-08-21 | — | — | EP | disclosed |
| WO-2023064343-A1 | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF | VANQUA BIO, INC. (US) | 2023-04-20 | — | — | WO | disclosed |