Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.57 |
| ▸ | CYBB | P04839 | 1/20 | 0.44 |
| ▸ | NOX5 | Q96PH1 | 1/20 | 0.44 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.44 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5424968 | 0.85 | USP30 (0.74) | USP30HRH3CYP11B2 | |
| SCHEMBL2703017 | 0.83 | HSD11B1 (0.46) | USP30HSD11B1 | |
| SCHEMBL3700174 | 0.83 | HSD11B1 (0.46) | USP30HSD11B1 | |
| SCHEMBL30328883 | 0.81 | USP30 (0.50) | USP30HRH3HDAC1HDAC8HDAC6 | |
| SCHEMBL5428076 | 0.80 | USP30 (0.63) | USP30HRH3 | |
| SCHEMBL12386415 | 0.79 | HSD11B1 (0.52) | USP30CYBBNOX5NOX4NOX1 | |
| SCHEMBL27370450 | 0.77 | USP30 (0.52) | USP30MEN1KMT2AHRH3HDAC1 | |
| SCHEMBL30328325 | 0.76 | USP30 (0.54) | USP30HRH3MAPTCYP11B2 | |
| SCHEMBL17082036 | 0.76 | USP30 (0.49) | USP30MEN1KMT2AHRH3MAPT | |
| SCHEMBL3497947 | 0.76 | USP30 (0.49) | USP30MEN1KMT2AHRH3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | disclosed |