SCHEMBL30331719

SCHEMBL30331719

[2H]C1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1

nearest known ligand 0.80

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 20/20 0.80
PARP3 Q9Y6F1 2/20 0.80
TNKS O95271 1/20 0.74
ADORA1 P30542 1/20 0.74
CDK6 Q00534 1/20 0.74
PDE3A Q14432 1/20 0.74
PARP6 Q2NL67 1/20 0.74
PARP15 Q460N3 1/20 0.74
PARP14 Q460N5 1/20 0.74
PARP10 Q53GL7 1/20 0.74
TIPARP Q7Z3E1 1/20 0.74
PARP8 Q8N3A8 1/20 0.74
PARP16 Q8N5Y8 1/20 0.74
PARP12 Q9H0J9 1/20 0.74
TNKS2 Q9H2K2 1/20 0.74
PARP11 Q9NR21 1/20 0.74
PARP2 Q9UGN5 1/20 0.74
PARP4 Q9UKK3 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30293115 0.94 PARP1 (0.89) PARP1PARP3
SCHEMBL19914129 0.93 PARP1 (0.84) PARP1PARP3
SCHEMBL30331782 0.93 PARP1 (0.84) PARP1PARP3
SCHEMBL19569971 0.92 PARP1 (0.90) PARP1PARP3TNKSADORA1CDK6
SCHEMBL864319 0.89 PARP1 (1.00) PARP1PARP3
SCHEMBL29434944 0.89 PARP1 (1.00) PARP1PARP3
SCHEMBL29463415 0.88 PARP1 (1.00) PARP1PARP3TNKSADORA1CDK6
SCHEMBL30205023 0.88 PARP1 (1.00) PARP1PARP3TNKSADORA1CDK6
SCHEMBL524782 0.88 PARP1 (1.00) PARP1PARP3TNKSADORA1CDK6
SCHEMBL27776285 0.88 PARP1 (0.87) PARP1PARP3TNKSADORA1CDK6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023061368-A1 HYDROXIMIC ACID DERIVATIVE AND USE THEREOF 成都自豪药业有限公司 2023-04-20 WO disclosed