⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18212638 | 0.70 | — | — | |
| SCHEMBL15548863 | 0.68 | — | — | |
| SCHEMBL21737202 | 0.68 | — | — | |
| SCHEMBL3323880 | 0.68 | — | — | |
| SCHEMBL12385448 | 0.65 | — | — | |
| SCHEMBL12340997 | 0.65 | ALDH1A1 (0.30) | — | |
| SCHEMBL16480100 | 0.65 | CYP3A4 (0.37) | — | |
| SCHEMBL22445479 | 0.64 | KDM4E (0.31) | — | |
| SCHEMBL12926031 | 0.64 | — | — | |
| SCHEMBL6071352 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8470861-B2 | Mitochondria-targeted antioxidant prodrugs and methods of use | UNIVERSITY OF ROCHESTER (US) | 2013-06-25 | — | — | US | disclosed |
| US-8470861-B2 | Mitochondria-targeted antioxidant prodrugs and methods of use | UNIVERSITY OF ROCHESTER (US) | 2013-06-25 | — | — | US | disclosed |
| US-8470861-B2 | Mitochondria-targeted antioxidant prodrugs and methods of use | UNIVERSITY OF ROCHESTER (US) | 2013-06-25 | — | — | US | disclosed |
| US-20100168198-A1 | Mitochondria-targeted antioxidant prodrugs and methods of use | UNIVERSITY OF ROCHESTER | 2010-07-01 | — | — | US | disclosed |
| US-20100168198-A1 | Mitochondria-targeted antioxidant prodrugs and methods of use | UNIVERSITY OF ROCHESTER | 2010-07-01 | — | — | US | disclosed |
| US-20100168198-A1 | Mitochondria-targeted antioxidant prodrugs and methods of use | UNIVERSITY OF ROCHESTER | 2010-07-01 | — | — | US | disclosed |
| US-20090306125-A1 | Mitochondria-Targeted Antioxidant Prodrugs and Methods of Use | UNIVERSITY OF ROCHESTER | 2009-12-10 | — | — | US | disclosed |
| US-20090306125-A1 | Mitochondria-Targeted Antioxidant Prodrugs and Methods of Use | UNIVERSITY OF ROCHESTER | 2009-12-10 | — | — | US | disclosed |
| US-20090306125-A1 | Mitochondria-Targeted Antioxidant Prodrugs and Methods of Use | UNIVERSITY OF ROCHESTER | 2009-12-10 | — | — | US | disclosed |
| EP-1954322-A2 | MITOCHONDRIA-TARGETED ANTIOXIDANT PRODRUGS AND METHODS OF USE | University of Rochester (US) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007062343-A2 | MITOCHONDRIA-TARGETED ANTIOXIDANT PRODRUGS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007062343-A2 | MITOCHONDRIA-TARGETED ANTIOXIDANT PRODRUGS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2007-05-31 | — | — | WO | disclosed |
| US-4898878-A | Antioxidant thiohistidine compounds | THE BOARD OF REGENTS OF THE UNIVERSITY OF WASHINGTON (US) | 1990-02-06 | — | — | US | disclosed |